The 15th RSC Nucleic Acids Forum was held at the Royal Society of Chemistry on the 12th of July in Mayfair, London. This meeting brought the UK and Irish Nucleic Acids Research community together to discuss exciting research involving the study of nucleic acids. At this event Bríonna presented a poster based on her current research which focuses on the “Development of new qPCR methodology to probe gene knockdown” while Nicoló presented his poster “Gene editing via nucleic acid ‘click’ chemistry”.