Publications

2024

73. Probing a Major DNA Weakness: Resolving the Groove and Sequence Selectivity of the Diimine Complex Λ-[Ru(phen)2phi]2+
T.D. Prieto Otoya, K.T. McQuaid, J. Hennessy, G. Menounou, A. Gibney, N.G. Paterson, D.J. Cardin, A. Kellett and C.J. Cardin, Angewandte Chemie, 2024, accepted (DOI: doi.org/10.1002/anie.202318863). [Highlight: Journal front cover (upcoming)]

72. Thiazole Orange-Carboplatin Triplex-Forming Oligonucleotide (TFO) Combination Probes Enhance Targeted DNA Crosslinking
J. Hennessy, P. Klimkowski, D. Singleton, A. Gibney, M. Coche, N.P. Farrell, A. H. El-Sagheer, T. Brown, and A. Kellett, RSC Medicinal Chemistry, 2024, accepted. [Highlight: Journal front cover (upcoming)]

2023

71. A Copper(II) Peptide Helicate Selectively Cleaves DNA Replication Foci in Mammalian Cells
A. Alcalde-Ordóñez, N. Barreiro-Piñeiro, B. McGorman, J. Gómez-González, D. Bouzada, F. Rivadulla, M. Eugenio Vázquez, A. Kellett, J. Martínez-Costas, M. Vázquez López, Chemical Science, 2023, Accepted (https://doi.org/10.1039/D3SC03303A). [Highlight: Inside cover]

70. Analysis of non-canonical three- and four-way DNA junctions
B. McGorman, S. Poole, M. Vázquez López, A. Kellett, Methods, 2023, 219, 30-38

69. A Click Chemistry-Based Artificial Metallo-Nuclease
A. Gibney, R. E. F. de Paiva, V. Singh, R. Fox, D. Thompson, J. Hennessy, C. Slator, C. McKenzie, P. Johansson, V. McKee, F. Westerlund, 
A. Kellett, Angewandte Chemie, 2023, accepted (DOI: 10.1002/anie.202305759) [Highlight: Hot Paper; Back Cover]

68. Third Generation Sequencing of Epigenetic DNA
B. Searle, M. Müller, T. Carell, A. Kellett, Angewandte Chemie, 2023, accepted (DOI: 10.1002/anie.202215704).

67. Two-Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies
S. O’Halloran, A. Pandit, A. Heise, A. Kellett, Advanced Science, 2023, accepted (DOI: 10.1002/advs.202204072). [Highlight: Journal Cover]

66. Antitumor copper(II) complexes with hydroxyanthraquinones and N,N-heterocyclic ligands
Í.P. de Souza, A.C.C. de Melo, B.L. Rodrigues, A. Bortoluzzi, S. Poole, Z. Molphy, V. McKee, A. Kellett, R.B. Fazzi, A.M. da Costa Ferreira, E.C. Pereira-Maia, Journal of Inorganic Biochemistry, 2023, accepted (DOI: 10.1016/j.jinorgbio.2023.112121).

2022

65. Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors, In: Biomimetic Radical Chemistry and Applications 2021
A. Banasiak, N. Zuin Fantoni, A. Kellett, J. Colleran, Molecules 2022, 27, 645. Chryssostomos Chatgilialoglu (Ed.), MDPI.

64. Enzymatic Synthesis of Chemical Nuclease Triplex-Forming Oligonucleotides with Gene-Silencing Applications
B. McGorman; N. Zuin Fantoni; S. O'Carroll; A. Ziemele; A. El-Sagheer; T. Brown; A. Kellett, Nucleic Acids Res., 2022, 50, 5467-5481.

63. Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors
A. Banasiak, N. Zuin Fantoni, A. Kellett, J. Colleran, Molecules 2022, 27, 645.

62. Copper(II) and silver(I)-1,10-phenanthroline-5,6-dione complexes interact with double-stranded DNA: further evidence of their apparent multi-modal activity towards Pseudomonas aeruginosa
A. C. M. Galdino, L. Viganor, M. M. Pereira, M. Devereux, M. McCann, M. H. Branquinha, Z. Molphy, S. O’Carroll, C. Bain, G. Menounou, A. Kellett, A. L. S. dos Santos, JBIC J. Biol. Inorg. Chem. 2022, 27, 201–213.

61. A Click Chemistry Approach to Targeted DNA Crosslinking with cis-Platinum(II) Modified Triplex Forming Oligonucleotides
J. Hennessy, B. McGorman, Z. Molphy, N.P. Farrell, D. Singleton, T. Brown, A. Kellett, Angewandte Chemie 2022, 61, 202110455 (doi.org/10.1002/anie.202110455)

2021

60. Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents
N. McStay, C. Slator, V. Singh, A. Gibney, F. Westerlund, A. Kellett, Nucleic Acids Res. 2021, accepted (doi.org/10.1093/nar/gkab817)

59. DNA-Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology
N. Z. Fantoni, T. Brown, A. Kellett, ChemBioChem 2021, 22, 2184.

58. Cover Feature: Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition (Chem. Eur. J. 3/2021)
N. Z. Fantoni, Z. Molphy, S. O'Carroll, G. Menounou, G. Mitrikas, M. G. Krokidis, C. Chatgilialoglu, J. Colleran, A. Banasiak, M. Clynes, S. Roche, S. Kelly, V. McKee, A. Kellett, Chem. Eur. J. 2021, 27, 828.

57. Polypyridyl-Based Copper Phenanthrene Complexes: Combining Stability with Enhanced DNA Recognition
N. Z. Fantoni, Z. Molphy, S. O'Carroll, G. Menounou, G. Mitrikas, M. G. Krokidis, C. Chatgilialoglu, J. Colleran, A. Banasiak, M. Clynes, S. Roche, S. Kelly, V. McKee, A. Kellett, Chem. Eur. J. 2021, 27, 971.

2020

56. Development of Gene‐Targeted Polypyridyl Triplex Forming Oligonucleotide Hybrids
N. Zuin Fantoni, B. McGorman, Z. Molphy, D. Singleton, S. Walsh, A. H. El-Sagheer, V. McKee, T. Brown, A. Kellett, ChemBioChem 2020, 21, 3563.

55. A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors
T. Lauria, C. Slator, V. McKee, M. Müller, S. Stazzoni, A. L. Crisp, T. Carell, A. Kellett, Chem. Eur. J. 2020, 26, 16782.

54. Design rules for environmental biodegradability of phenylalanine alkyl ester linked ionic liquids
Suk M., Hasß A., Westphal J., Jordan A., Kellett A., Kapitanov I. V., Karpichev Y., Gathergood N., Kümmerer K. Green Chem., Accepted: DOI: 10.1039/d0gc00918k, 2020.

53. Copper bis-Dipyridoquinoxaline is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove
Molphy Z., McKee V., Kellett A. In: Biomimetic Radical Chemistry and Applications; Editor: Chryssostomos Chatgilialoglu; Publisher: MDPI, Basel, Switzerland; ISBN 978-3-03928-392-7; 2020.

52. Oxidative DNA Cleavage with Clip‐Phenanthroline Triplex Forming Oligonucleotide Hybrids
Panattoni A., El-Sagheer A.H., Brown T., Kellett A., Hocek M. ChemBioChem, 21(7): 991-1000, 2020.

51. Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes
Barrett S., De Franco M., Kellett A., Dempsey E., Marzano C., Erxleben A., Gandin V., Montagner D. J. Biol. Inorg. Chem., 25: 49-60, 2020.

50. Cu(II) phenanthroline–phenazine complexes dysregulate mitochondrial function and stimulate apoptosis
Rochford G., Molphy Z., Kavanagh K., McCann M., Devereux M., Kellett A., Howe O. Metallomics, 12: 65-78, 2020.

2019

49. Copper bis-Dipyridoquinoxaline is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove
Molphy Z., McKee V., Kellett A. Molecules, 24(23): 4301, 2019.

48. Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N′-dialkyl-9,9′-biacridylidenes
Krokidis M.G, Molphy Z., Efthimiadou E.K., Kokoli M., Argyri S-M., Dousi I., Masi A., Papadopoulos K., Kellett A., Chatgilialoglu C. Biomolecules, 9(5): 177, 2019.

47. Recent Advances in Anticancer Copper Compounds
Kellett A., Molphy Z, McKee V and Slator C. In: Metal-based Anticancer Agents, Editors: Casini A., Vessières A., Meier-Menches S. M., Publisher: Royal Society of Chemistry (Cambridge), Chapter 4, 91-119, 2019.

46. A new class of prophylactic metallo-antibiotic possessing potent anti-cancer and anti-microbial properties
Ude Z., Kavanagh K., Twamley B., Pour M., Gathergood N., Kellett A., Marrmion C. J. Dalton Trans., 48: 8578-8593, 2019. [Front Cover]

45. Synthesis, self-assembly, bacterial and fungal toxicity, and preliminary biodegradation studies of a series of L-phenylalanine-derived surface-active ionic liquids
Kapitanov, I. V., Jordan A., Karpichev Y., Spulak M., Perez L., Kellett A., Kümmerer K., Gathergood N. Green Chem., 21: 1777-1794, 2019.

44. Exploring the DNA binding, oxidative cleavage, and cytotoxic properties of new ternary copper(II) compounds containing 4-aminoantipyrine and N,N-heterocyclic co-ligands
P.de Souza I., de P.Machado B., B.de Carvalho A., Binatti I., Krambrock K., Molphy Z., Kellett A., C.Pereira-Maia E., P. Silva-Caldeira P. J. Mol. Struct., 1178: 18-28, 2019.

43. Molecular methods for assessment of non-covalent metallodrug–DNA interactions
Kellett A., Molphy Z., Slator C., McKee V., Farrell N.P. ChemSocRev, 48: 971-988, 2019. [Cover Article]

42. Efficient DNA Condensation by a C3‐Symmetric Codeine Scaffold
McStay N., Reilly A., M., Gathergood N., Kellett A. ChemPlusChem, 84(1): 38-42, 2019.

41. Frontispiece: Polypyridyl-based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease
Zuin Fantoni N., Molphy Z., Slator C., Menounou G., Toniolo, G., Mitrikas G., McKee V., Chatgilialoglu C., Kellett A. Chem. Eur. J., 25(1): 2019.

40. Polypyridyl-based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease
Zuin Fantoni N., Molphy Z., Slator C., Menounou G., Toniolo, G., Mitrikas G., McKee V., Chatgilialoglu C., Kellett A. Chem. Eur. J., 25(1): 221-237, 2019. [Hot Paper]

2018

39. [Cu(TPMA)(Phen)](ClO4)2: metallo-drug nanocontainer delivery and membrane lipidomics of a neuroblastoma cell line coupled with a liposome biomimetic model focusing on fatty acid reactivity
Toniolo, G., Louka, M., Menounou, G., Fantoni, N.; Mitrikas, G.; Efthimiadou, E., Masi, A., Bortolotti, M., Polito, L., Bolognesi, A., Kellett, A., Ferreri, C., Chatgilialoglu, C. ACS Omega, 3(11): 15952-15965, 2018. 

38. A Phosphate-Targeted Dinuclear Cu(II) Complex Combining Major Groove Binding and Oxidative DNA Cleavage
Molphy Z., Montagner D., Bhat S., Slator C., Long C., Erxleben A., Kellett A. Nucleic Acids Res., 46(19): 9918-9931, 2018. 

37. Innovative DNA-Targeted Metallo-Prodrug Strategy combining Histone Deacetylase Inhibition with Oxidative Stress
McGivern T., Slator C., Kellett A., Marmion C. Molecular Pharmaceutics, 15(11): 5058-5071, 2018. 

36. In-vivo evaluation of the response of Galleria mellonella larvae to novel copper(II) phenanthroline-phenazine complexes
Rochford G., Molphy Z., Browne N., Surlis C., Devereux M., McCann M., Kellett A., Howe O., Kavanagh K. J. Inorg. Biochem., 186: 135-146, 2018. 

35. Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination
Slator C., Molphy Z., Long C., McKee V., Brown T., Kellett A. Nucleic Acids Res., 46(6): 2733-2750, 2018. 

2017

34. Opioid architectures as new DNA binding molecules
McStay N., Molphy Z., Gathergood N., Kellett A. Symmetry, 28(2): 195-161, 2017.

33. Triggering autophagic cell death with a di-manganese(II) developmental therapeutic
Slator C., Molphy Z., McKee V., Kellett A. Redox Biol., 12: 150-161, 2017.

32. C3-Symmetric Opioid Scaffolds are pH-Responsive DNA Condensation Agents
McStay N., Molphy Z., Coughlan A., Cafolla, A., McKee, V., Gathergood, N., Kellett, A. Nucleic Acids Res., 45(2): 527-540, 2017. 

2016

31. Radical-induced purine lesion formation is dependent on DNA helical topology
Terzidis M.A., Prisecaru A., Molphy Z., Barron N., Randazzo A., Dumont E., Krokidis M.G., Kellett A., Chatgilialoglu C. Free Rad. Res., 50: S91-S101, 2016.

30. Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics 
Kelly P.S., McSweeney S., Clynes M., Meleady P., Barron N., Coleman O., Henry M., Carillo S., Bones J., Chandron D., Kellett A. Biotechnol. Progress, 32(6): 1547–1558, 2016.

29. Water-soluble and photo-stable silver(I) dicarboxylate complexes containing 1,10-phenanthroline ligands: Antimicrobial and anticancer chemotherapeutic potential, DNA interactions and antioxidant activity
Thornton L., Dixit V., Assad L., Ribeiro T., Queiroz D., Kellett A., Casey A., Colleran J., Pereira M., Rochford G., McCann M., O'Shea D., Dempsey R., McClean S., Kia A., Walsh M., Creaven B., Howe O., Devereux M. J. Inorg. Biochem., 159: 120-132, 2016.

28. [Cu(o-phthalate)(phenanthroline)] Exhibits Unique Superoxide-Mediated NCI-60 Chemotherapeutic Action through Genomic DNA Damage and Mitochondrial Dysfunction
Slator C., Barron N., Howe O., Kellett A. ACS Chem. Biol., 11(1): 159–171, 2016.

27. Anti-Pseudomonas aeruginosa activity of 1,10-phenanthroline-based drugs against both planktonic- and biofilm-growing cells
Viganor, L., Galdino, A.C., Nunes, A.P., Santos, K., Branquinha M., Devereux, M., Kellett, A., McCann, M., Santos, A. J.  J. Antimicrob. Chemother., 71(1): 128-134, 2016.

2015

26. DNA Oxidation Profiles of Copper Phenanthrene Chemical Nucleases
Molphy Z., Slator C., Chatgilialoglu C., Kellett A. In: Radiation and Oxidative DNA Damages, Editors: Monari A., Dumont E. and Chatgilialoglu C. Publishers: Frontiers Media (Lausanne), doi.org/10.3389/978-2-88919-660-9, 2015.

25. Genome Engineering with Synthetic Copper Nucleases
Fantoni N., Lauria T., Kellett A.  Synlett., 26(19): 2623-2626, 2015. [Invited Manuscript - Synpact]

24. Protein engineering with artificial chemical nucleases
Larragy R., Fitzgerald J., Prisecaru A., McKee V., Leonard P. and Kellett A. Chem. Commun., 51, 12908-12911, 2015. [Front Cover]

23. DNA Oxidation Profiles of Copper Phenanthrene Chemical Nucleases
Molphy Z., Slator C., Chatgilialoglu C., Kellett A. Front. Chem., 3(18): 1-9, 2015.

2014

22. The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes
Prisecaru A., Molphy Z., Kipping R.G., Peterson E.J., Qu Y., Kellett A., and Farrell N.P. Nucleic Acids Res., 42(22): 13474-13487, 2014.

21. Copper Phenanthrene Oxidative Chemical Nucleases
Molphy Z., Prisecaru A., Slator C., Barron, N., McCann M., Colleran J., Chandran D., Gathergood N., Kellett A., Inorg. Chem., 53(10): 5392-5404, 2014.

2013

20. Synthesis, Structure and Biological Activity of Silver(I) Complexes of Substituted Imidazoles
McCann M., Curran R., Ben-Shoshana M., McKee V., Devereux M., Kavanagh K., Kellett A. Polyhedron, 56, 180-188, 2013.

19. Regulating Bioactivity of Cu2+ Bis-1,10-Phenanthroline Artificial Metallonucleases with Sterically Functionalised Pendant Carboxylates
Prisecaru A., Mckee V., Howe O., Rochford G., McCann M, Colleran J., Barron N., Pour M., Gathergood N. and Kellett A. J. Med. Chem., 56(21): 8599-8615, 2013.

18. A new phenanthroline-oxazine ligand: synthesis, coordination chemistry and atypical DNA binding interaction
McCann M., McGinley J., Ni K., O'Connor M., Kavanagh K., McKee V., Colleran J., Devereux M., Gathergood N., Barron N., Prisecaru A. and Kellett A. Chem. Commun., 49, 2341-2343, 2013.

17. Metal-Based Antimicrobial Protease Inhibitors
Kellett A., Prisecaru A., Slator C., Molphy Z., McCann M. Curr. Med. Chem., 20(25): 3134-3151, 2013.

2012

16. Copper(II) complexes of salicylic acid combining superoxide dismutase mimetic properties with DNA binding and cleaving capabilities exhibit low toxicity and display promising chemotherapeutic potential with fast acting in-vitro cytotoxicity against cisplatin sensitive and resistant cancer cell lines
O'Connor M., Kellett A., McCann M., Rosair G., McNamara M., Howe O., Creaven B., McClean S., Foltyn-Arfa Kia A., O'Shea D., Devereux M. J. Med. Chem., 55 (5), 1957-1968, 2012.

15. DNA Cleavage Reactions of the Dinuclear Chemotherapeutic Agent Copper(II) Bis-1,10-Phenanthroline Terephthalate
Kellett A., McCann M., Howe O., O'Connor M., Devereux M. Int. J. Clin. Pharmacol. Ther., 50 (1), 79-81, 2012.

14. Radical Induced DNA Damage by Cytotoxic Square-Planar Copper(II) Complexes Incorporating o-Phthalate and 1,10-Phenanthroline or 2,2'-Dipyridyl
Kellett A., Howe O., O'Connor M., McCann M., Creaven B., McClean S., Foltyn-Arfa Kia A., Casey A., Devereux M. Free Rad. Biol. Med., 53(3): 564-576, 2012.

13. Potent oxidative DNA cleavage by the di-copper cytotoxin: [Cu2(terephthalate)(1,10-phen)4]2+
Prisecaru A., Devereux M., Barron N., McCann M., Colleran J., Casey A., McKee V., Kellett A. Chem. Commun., 48 (55), 6906-6908, 2012.

12. Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity
McCann M., Curran R., Ben-Shoshan M., McKee V., Tahir A., Devereux M., Kavanagh K., Creaven B.,  Kellett A. Dalton Trans., 41(21): 6516-6527, 2012.

11. In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(II) and silver(I) complexes
McCann M., Santos A., da Silva B., Romanos M., Pyrrho A., Devereux M., Kavanagh K., Fichtner I., Kellett A. Tox. Res., 1 (1), 47-54, 2012.
[Cover Article]
[Editorial Highlight]

10. Antimicrobial Action of Chelating Agents: Repercussions on the Microorganism Development, Virulence and Pathogenesis
Santos A.L.S., Sodre C.L., Valle R.S., Silva B.A., Abi-chacra E.A., Silva L.V., Souza-Goncalves A.L., Sangenito L.S., Goncalves D.S., Souza L.O.P., Palmeira V.F., d'Avila-Levy C.M., Kneipp L.F., Kellett A., McCann M., Branquinha M.H. Curr. Med. Chem., 19 (17), 2715-2737, 2012.

9. Deciphering the Antimicrobial Activity of Phenanthroline Chelators
McCann M., Kellett A., Kavanagh K., Devereux M., Santos A.L.S. Curr. Med. Chem., 19(17): 2703-2714, 2012.

2011

8. Water-soluble bis(1,10-phenanthroline) octanedioate Cu2+ and Mn2+ complexes with unprecedented nano and picomolar in vitro cytotoxicity: promising leads for chemotherapeutic drug development
Kellett A., O'Connor M., McCann M., Howe O., Casey A., McCarron P., McNamara M., Kennedy S., May D.D., Skell P.S., O'Shea D., Devereux M. Med. Chem. Comm., 2(7): 569-676, 2011.
[Cover Article]
[Editorial Highlight]

7. Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with self-activating metallo-nuclease and DNA binding properties
Kellett A., O'Connor M., McCann M., McNamara M., Lynch P., Rosair G., McKee V., Creaven B., Walsh M., McClean S., Foltyn A., O'Shea D., Howe O., Devereux M. Dalton Trans., 40, 1024-1027, 2011.

2010

6.  Hexakis(prop-2-enamide)copper(II) bis(perchlorate) and hexakis(prop-2-enamide)manganese(II) bis(perchlorate) 
Kellett, A., Rosair G., Devereux M., McNamara M., McCann M. Acta Cryst. C., 66(11), M358-M362, 2010.

5. Biological activity and coordination modes of copper(II) complexes of Schiff base-derived coumarin ligands
Creaven B. S., Czegledi E., Devereux M., Enyedy E. A., Foltyn-Arfa Kia A., Karcz D., Kellett A., McClean S., Nagy N. V., Noble A., Rockenbauer A.,Szabo-Planka T., Walsh M. Dalton Trans., 39(45): 10854-10865, 2010.

2009

4. Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity
Creaven B. S., Devereux M., Karcz D., Kellett A., McCann M., Noble A., Walsh M.  J. Inorg. Biochem., 103(9): 1196-1203, 2009.

2005

1. Synthesis, superoxide dismutase mimetic and anticancer activities of metal complexes of 2,2-dimethylpentanedioic acid (2dmepdaH(2)) and 3,3-dimethylpentanedioic acid(3dmepdaH(2)): X-ray crystal structures of [Cu(3dmepda)(bipy)] and [Cu(2dmepda)(bipy)(EtOH)] (bipy=2,2' bipyridine)
Devereux M., McCann M., O'Shea D., O'Connor M., Kiely E., McKee V., Naughton D., Fisher A., Kellett A., Walsh M., Egan D., Deegan C. Bioinorg. Chem. Appl., doi.org/10.1155/BCA/2006/80283Synthesis, catalase, superoxide dismutase and antitumour activities of copper(II) carboxylate complexes incorporating benzimidazole, 1,10-phenanthroline and bipyridine ligands: X-ray crystal structures of [Cu(BZA)(2)(bipy)(H2O)], [Cu(SalH)(2)(BZDH)(2)] and [Cu(CH3COO)(2)(5,6-DMBZDH)(2)] (SalH(2) =salicylic acid; BZAH = benzoic acid; BZDH = benzimidazole and 5,6-DMBZDH=5,6-dimethylbenzimidazole), 2005.