A mini symposium in honour of Professors Jacqueline Barton and Peter Dervan was held in Trinity College Dublin on May 17th. Prof. Jackie Barton gave the prestigious Cocker Lecture entitled “DNA Signalling” and was also awarded the RSC Centenary Prize. Thanks to Professors Sylvia Draper, Peter Dunne, Isabel Rozas for the invite to present on “Recent Advances in Copper(II) Artificial Metallonuclease Design” at this symposium.